TB-500 Dosing Guide

TB-500 Dosing Calculator

Use this calculator to determine your personalized TB-500 dose based on body weight and treatment goals:

Standard Dosing Protocols

Loading Phase (Weeks 1-4 to 1-6)

The loading phase uses higher doses administered twice weekly to rapidly saturate tissues and achieve therapeutic levels:

• Conservative: 2-5 mg twice weekly (4-10 mg/week total)
• Standard: 5-7.5 mg twice weekly (10-15 mg/week total)
• Intensive: 7.5-10 mg twice weekly (15-20 mg/week total)

Schedule: Monday/Thursday or Tuesday/Friday (3-4 days apart)

Duration: 4-6 weeks, then transition to maintenance

Maintenance Phase (Weeks 5-12+)

After loading, reduce frequency to once weekly while maintaining therapeutic effects:

• Conservative: 2-5 mg once weekly
• Standard: 5-7.5 mg once weekly
• Intensive: 7.5-10 mg once weekly

Schedule: Same day each week (e.g., every Monday)

Duration: 8-12 weeks total treatment, then reassess

Cycling Recommendations

• Acute Injuries: 8-12 week protocol, then stop if healed
• Chronic Conditions: 12 weeks on, 4-8 weeks off, repeat as needed
• Prevention/Maintenance: Lower doses (2-5 mg) weekly ongoing, or cycle 8 weeks on/4 weeks off
• Athletic Performance: Use during intense training blocks, cycle off during deload periods

Condition-Specific Dosing

Acute Injuries (Muscle Tears, Sprains, Strains)

• Loading: 7.5-10 mg twice weekly for 4 weeks
• Maintenance: 5-7.5 mg once weekly for 4-8 weeks
• Total Duration: 8-12 weeks
• Expected Results: Accelerated healing, reduced inflammation, improved tissue quality

Chronic Tendinopathy (Tendonitis, Tendinosis)

• Loading: 5-7.5 mg twice weekly for 6 weeks
• Maintenance: 5 mg once weekly for 6-12 weeks
• Total Duration: 12-18 weeks (chronic conditions require longer treatment)
• Expected Results: Gradual improvement over months, reduced pain, improved function

Post-Surgical Recovery

• Pre-Surgery: 5-7.5 mg twice weekly for 2 weeks before surgery (if possible)
• Post-Surgery: 7.5-10 mg twice weekly starting 3-7 days post-op for 4-6 weeks
• Maintenance: 5-7.5 mg once weekly for 4-8 weeks
• Expected Results: Faster wound healing, reduced scarring, improved tissue quality

Hair Regrowth

• Loading: 2-5 mg twice weekly for 4-8 weeks
• Maintenance: 2-5 mg once weekly for 12-24 weeks
• Total Duration: 6-12 months for visible results
• Expected Results: Improved scalp blood flow, follicle regeneration (combine with topical GHK-Cu)

Cardiovascular Health / Post-MI

• Loading: 5-10 mg twice weekly for 4-6 weeks
• Maintenance: 5 mg once weekly for 8-12 weeks
• Note: Requires medical supervision, based on animal cardiac research
• Expected Results: Improved cardiac function, reduced scar tissue, enhanced angiogenesis

Administration Guidelines

Reconstitution Instructions

1. Materials Needed:
   • TB-500 lyophilized powder (typically 5mg vial)
   • Bacteriostatic water (2ml recommended)
   • Alcohol swabs
   • Insulin syringes (1ml with 29-31 gauge needles)
2. Reconstitution Process:
   • Clean vial tops with alcohol swabs
   • Draw 2ml bacteriostatic water into syringe
   • Slowly inject water into TB-500 vial (aim for side of vial, not directly on powder)
   • Gently swirl (do not shake) until powder dissolves completely (1-2 minutes)
   • Solution should be clear and colorless
3. Concentration: 2ml in 5mg vial = 2.5 mg/ml
   • 0.1 ml (10 units) = 0.25 mg
   • 0.2 ml (20 units) = 0.5 mg
   • 0.4 ml (40 units) = 1 mg
   • 1.0 ml (100 units) = 2.5 mg
   • 2.0 ml (200 units) = 5 mg
4. Storage: Refrigerate immediately, use within 30 days

Injection Technique

Subcutaneous Injection (Most Common)

1. Clean injection site with alcohol swab (abdomen, thigh, or upper arm)
2. Pinch skin to create a fold
3. Insert needle at 45-90 degree angle
4. Inject slowly over 5-10 seconds
5. Withdraw needle and apply gentle pressure
6. Rotate injection sites to prevent tissue irritation

Intramuscular Injection (Alternative)

1. Common sites: Deltoid (shoulder), vastus lateralis (thigh), gluteus (buttock)
2. Clean site with alcohol swab
3. Insert needle at 90 degree angle into muscle
4. Aspirate slightly to ensure not in blood vessel
5. Inject slowly, withdraw, apply pressure

Timing Considerations

• Time of Day: No specific requirement, but consistency helps
• With Food: Can be taken with or without food
• Pre/Post Workout: Some prefer post-workout for recovery, but timing is flexible
• Before Bed: Aligns with natural tissue repair during sleep

Combining TB-500 with Other Peptides

TB-500 + BPC-157 (Most Popular Stack)

Synergistic Effects: Complementary healing mechanisms

• TB-500: 5-7.5 mg twice weekly (loading) or once weekly (maintenance)
• BPC-157: 250-500 mcg twice daily
• Benefits: TB-500 promotes angiogenesis and stem cell migration, BPC-157 enhances local healing and reduces inflammation
• Best For: Acute injuries, post-surgical recovery, chronic tendinopathy
• Duration: 8-12 weeks combined protocol

TB-500 + GHK-Cu (Hair Regrowth Stack)

• TB-500: 2-5 mg once weekly (systemic effects)
• GHK-Cu: 2% topical solution twice daily to scalp
• Benefits: TB-500 improves scalp blood flow, GHK-Cu stimulates follicles directly
• Duration: 6-12 months for visible results

TB-500 + Growth Hormone Peptides

• TB-500: 5 mg once weekly
• CJC-1295/Ipamorelin: Standard dosing protocols
• Benefits: Enhanced tissue repair, improved recovery, synergistic anabolic effects
• Best For: Athletic performance, injury prevention, anti-aging

Expected Timeline and Results

Week-by-Week Progression

• Week 1-2: Minimal noticeable effects, peptide accumulating in tissues
• Week 2-3: Reduced inflammation, improved range of motion, decreased pain
• Week 3-4: Noticeable healing progress, improved tissue quality
• Week 4-8: Continued improvement, tissue remodeling, strength gains
• Week 8-12: Maximum benefits, sustained healing, reduced need for ongoing treatment

Factors Affecting Results

• Injury Severity: Acute injuries respond faster than chronic conditions
• Age: Younger individuals typically see faster results
• Overall Health: Good nutrition, sleep, and stress management enhance results
• Dose: Higher doses may produce faster results but increase cost
• Consistency: Regular dosing schedule critical for sustained benefits
• Combination Therapy: Stacking with BPC-157 or other peptides enhances outcomes

Safety and Monitoring

Common Side Effects

• Injection Site Reactions: Redness, mild swelling, temporary discomfort (5-10% of users)
• Fatigue: Temporary tiredness, especially in first 1-2 weeks (10-15% of users)
• Headache: Mild, transient headaches (5% of users)
• Flushing: Temporary facial flushing (rare)

Rare/Serious Concerns

• Cancer Concerns: Theoretical risk due to angiogenesis promotion (no human data)
• Contraindication: Active cancer or history of cancer (avoid use)
• Pregnancy/Breastfeeding: No safety data, avoid use

Monitoring Recommendations

• Baseline Assessment: Document injury/condition before starting
• Weekly Check-ins: Track pain levels, range of motion, function
• Photos: Take photos of visible injuries for comparison
• Blood Work: Consider baseline and follow-up labs if using long-term
• Medical Supervision: Recommended for serious injuries or conditions

Troubleshooting

Not Seeing Results After 4 Weeks?

• Increase dose by 2.5-5 mg per injection
• Ensure proper reconstitution and storage
• Verify peptide quality and purity (should be >98%)
• Consider adding BPC-157 for synergistic effects
• Extend loading phase to 6-8 weeks
• Address underlying factors (nutrition, sleep, stress)

Excessive Fatigue?

• Reduce dose by 25-50%
• Inject in evening rather than morning
• Ensure adequate sleep and recovery
• Typically resolves after 2-3 weeks

Injection Site Reactions?

• Rotate injection sites more frequently
• Ensure proper injection technique
• Allow reconstituted solution to reach room temperature before injecting
• Consider switching from SubQ to IM injection

Results Plateaued?

• May have reached maximum benefit for current injury
• Consider transitioning to maintenance dose
• Take 2-4 week break, then restart if needed
• Add complementary therapies (physical therapy, etc.)

Cost Considerations

Typical Costs

• 5mg Vial: $30-60 (depending on source and quality)
• Loading Phase: $120-240/month (10-20 mg/week)
• Maintenance Phase: $60-120/month (5-10 mg/week)
• 8-Week Protocol: $400-800 total
• 12-Week Protocol: $600-1,200 total

Cost-Saving Strategies

• Buy in bulk (multiple vials at once for discount)
• Use conservative dosing (still effective for many)
• Transition to maintenance phase as soon as appropriate
• Cycle protocols rather than continuous use
• Combine with lower-cost peptides like BPC-157

Related Resources

• TB-500 Overview
• TB-500 Side Effects
• TB-500 Safety Information
• BPC-157 (Synergistic Peptide)
• Injury Healing Protocol
• Injectable Delivery Guide