Cognitive Enhancement & Focus Protocol

Protocol Overview

This protocol combines two complementary Russian nootropic peptides—Semax for cognitive enhancement and Selank for anxiety reduction—to create a powerful synergistic stack for mental performance, learning, memory, and stress resilience. Unlike stimulant-based nootropics, this peptide combination works through neuroplasticity, neuroprotection, and neurotransmitter modulation to produce sustainable cognitive improvements without tolerance or dependence.

The Semax + Selank stack has been used by Russian cosmonauts, military personnel, and students for decades, with extensive research supporting its safety and efficacy. While not FDA-approved in the US, the combination represents one of the most well-researched peptide nootropic stacks available.

Expected Benefits

• Enhanced focus and concentration: Improved ability to sustain attention on demanding tasks for extended periods
• Improved memory formation and recall: Better encoding of new information and retrieval of stored memories
• Increased mental clarity: Reduced brain fog, sharper thinking, faster processing speed
• Reduced anxiety without sedation: Calm, focused state without drowsiness or impairment
• Better stress resilience: Improved ability to handle cognitive demands under pressure
• Neuroprotective effects: Protection against oxidative stress, inflammation, and age-related cognitive decline
• Enhanced learning capacity: Faster acquisition of new skills and information
• Improved mood and motivation: Subtle mood elevation and increased drive

Who This Protocol Is For

• Students: During exam periods, thesis writing, or intensive study
• Professionals: With demanding cognitive work (programming, writing, analysis, strategy)
• Entrepreneurs: Managing multiple projects and high-stress decision-making
• Creatives: Writers, designers, artists seeking enhanced focus and flow states
• Aging individuals: Experiencing mild cognitive decline or seeking cognitive preservation
• High-performers: Athletes, executives, anyone seeking cognitive optimization
• Recovery patients: Post-stroke, TBI, or other neurological conditions (under medical supervision)

Timeline of Effects

• Day 1-3: Subtle improvements in focus and reduced anxiety (Selank effects more noticeable)
• Week 1: Clearer thinking, improved concentration, better stress handling
• Week 2-4: Enhanced memory formation, faster learning, sustained mental energy
• Week 4-8: Peak cognitive benefits, improved baseline mental performance
• Week 8-12: Sustained improvements, potential for long-term neuroplastic changes
• Post-cycle: Many benefits persist for weeks after discontinuation

Understanding Semax and Selank

Semax: The Cognitive Enhancer

Semax is a synthetic heptapeptide (7 amino acids) based on a fragment of ACTH (adrenocorticotropic hormone). Developed by the Russian Academy of Sciences in the 1980s, it's approved in Russia for treating stroke, cognitive impairment, and various neurological conditions.

Mechanisms of action:

• BDNF upregulation: Increases brain-derived neurotrophic factor, promoting neuroplasticity and neurogenesis
• NGF enhancement: Boosts nerve growth factor, supporting neuron health and connectivity
• Neurotransmitter modulation: Increases dopamine, serotonin, and acetylcholine in key brain regions
• Neuroprotection: Protects against oxidative stress, excitotoxicity, and inflammation
• Cerebral blood flow: Improves oxygen and nutrient delivery to brain tissue
• Gene expression: Modulates expression of genes involved in learning, memory, and neuroprotection

Primary effects:

• Enhanced focus and concentration
• Improved memory encoding and consolidation
• Faster mental processing speed
• Increased mental energy and stamina
• Better pattern recognition and problem-solving
• Neuroprotection against stress and aging

Selank: The Anxiolytic Nootropic

Selank is a synthetic peptide based on tuftsin, an immunomodulatory peptide. Also developed by the Russian Academy of Sciences, it's approved in Russia for treating anxiety disorders and has nootropic properties.

Mechanisms of action:

• GABA modulation: Enhances GABAergic neurotransmission without direct GABA receptor binding
• Serotonin regulation: Increases serotonin metabolism and receptor sensitivity
• Enkephalin stabilization: Prevents breakdown of endogenous enkephalins (natural opioid peptides)
• BDNF upregulation: Like Semax, increases neurotrophic factors
• Immune modulation: Balances immune function, reducing inflammation
• Gene expression: Affects genes related to stress response and neuroplasticity

Primary effects:

• Reduced anxiety without sedation
• Improved stress resilience
• Enhanced focus (by reducing distracting anxiety)
• Better emotional regulation
• Improved sleep quality
• Subtle mood elevation
• Immune system support

Why They Work Synergistically

Semax and Selank complement each other perfectly:

• Semax provides stimulation (focus, energy, drive) while Selank prevents overstimulation (anxiety, jitteriness)
• Both increase BDNF through different pathways, creating additive neuroplastic effects
• Semax enhances dopamine (motivation, reward) while Selank enhances serotonin (mood, emotional stability)
• Semax improves cognitive performance while Selank reduces performance anxiety
• Both provide neuroprotection through complementary mechanisms

The result is a "calm focus" state—alert, energized, and motivated, but without anxiety, jitteriness, or mental tension. This is ideal for sustained cognitive work, learning, and high-pressure situations.

Complete Dosing Protocols

Protocol 1: Beginner Stack (4-8 Weeks)

Best for: First-time users, those sensitive to nootropics, or seeking mild cognitive enhancement

Semax dosing:

• Form: Semax 0.1% nasal spray (1 mg/mL)
• Dose: 300-600 mcg per day (3-6 sprays total, 100 mcg per spray)
• Timing: Morning (upon waking) and/or early afternoon
• Administration: 1-2 sprays per nostril, alternating nostrils
• Duration: 4-8 weeks, then 2-4 week break

Selank dosing:

• Form: Selank 0.15% nasal spray (1.5 mg/mL)
• Dose: 250-500 mcg per day (2-3 sprays total, ~150 mcg per spray)
• Timing: Morning and/or as needed for anxiety
• Administration: 1 spray per nostril, can repeat in afternoon if needed
• Duration: 4-8 weeks, then 2-4 week break

Daily schedule example:

• 7:00 AM: 2 sprays Semax (1 per nostril) + 2 sprays Selank (1 per nostril)
• 1:00 PM (optional): 1-2 sprays Semax if afternoon cognitive demands
• As needed: 1 spray Selank for anxiety or stress

Expected results:

• Noticeable improvements in focus and reduced anxiety within 3-7 days
• Enhanced memory and learning by week 2-3
• Peak benefits at week 4-6
• Minimal side effects at these doses

Protocol 2: Standard Stack (8-12 Weeks)

Best for: Experienced users, demanding cognitive work, or significant cognitive enhancement goals

Semax dosing:

• Form: Semax 1% nasal spray (10 mg/mL) or injectable
• Dose: 600-1,200 mcg per day
• Timing: Split into 2-3 doses (morning, midday, early afternoon)
• Administration: Nasal spray (2-3 sprays, 2-3x daily) or subcutaneous injection (600 mcg once daily)
• Duration: 8-12 weeks, then 4-6 week break

Selank dosing:

• Form: Selank 0.15% nasal spray or injectable
• Dose: 500-1,000 mcg per day
• Timing: Split into 2-3 doses throughout day
• Administration: Nasal spray (3-6 sprays daily) or subcutaneous injection (500 mcg once daily)
• Duration: 8-12 weeks, then 4-6 week break

Daily schedule example:

• 7:00 AM: 400 mcg Semax + 300 mcg Selank (nasal)
• 12:00 PM: 400 mcg Semax + 300 mcg Selank (nasal)
• 3:00 PM: 400 mcg Semax (optional, if late work demands)
• As needed: Additional Selank for anxiety/stress

Expected results:

• Significant cognitive enhancement within first week
• Dramatic improvements in focus, memory, and mental stamina by week 2-4
• Peak performance at week 6-10
• Potential for lasting neuroplastic changes

Protocol 3: Advanced Stack with NAD+ (12+ Weeks)

Best for: Serious cognitive optimization, aging-related decline, or recovery from neurological injury

Core peptides:

• Semax: 600-1,200 mcg daily (as above)
• Selank: 500-1,000 mcg daily (as above)
• NAD+: 50-100 mg subcutaneous injection, 2-3x per week

Rationale for NAD+ addition:

• NAD+ supports mitochondrial function, providing cellular energy for enhanced cognition
• Synergizes with Semax/Selank neuroprotection
• Supports DNA repair and cellular health
• May enhance neuroplasticity and BDNF effects
• Provides anti-aging benefits beyond cognition

Weekly schedule example:

• Daily: Semax + Selank as per Standard Stack
• Monday, Wednesday, Friday: 50-100 mg NAD+ subcutaneous injection (morning)
• Duration: 12-16 weeks, then 6-8 week break

Protocol 4: Exam/High-Stress Intensive (2-4 Weeks)

Best for: Short-term intensive cognitive demands (exams, project deadlines, competitions)

Semax dosing:

• Dose: 1,200-1,800 mcg per day (higher end of range)
• Timing: 3-4 doses throughout day
• Duration: 2-4 weeks maximum, then mandatory 4+ week break

Selank dosing:

• Dose: 1,000-1,500 mcg per day
• Timing: 3-4 doses, with extra doses before high-stress events
• Duration: 2-4 weeks maximum

Important notes:

• This is a short-term intensive protocol, not sustainable long-term
• Mandatory break after completion to avoid tolerance
• Monitor for side effects (headache, overstimulation)
• Ensure adequate sleep, nutrition, and hydration
• Consider adding L-theanine or magnesium if overstimulated

Administration Techniques

Nasal Spray Administration

Most users prefer nasal spray for convenience and rapid onset:

Proper technique:

1. Blow nose gently to clear nasal passages
2. Shake spray bottle gently
3. Tilt head slightly forward (not back)
4. Insert nozzle into nostril, aim toward outer wall (not septum)
5. Spray while inhaling gently through nose
6. Avoid sniffing hard or blowing nose for 5-10 minutes
7. Alternate nostrils between doses

Tips for optimal absorption:

• Use on empty stomach or 30+ minutes after eating
• Stay upright for 10-15 minutes after administration
• Avoid nasal decongestants which can reduce absorption
• If congested, wait until nasal passages clear
• Clean spray nozzle regularly to prevent contamination

Subcutaneous Injection

Injectable forms provide more consistent dosing and longer duration:

Reconstitution:

• Use bacteriostatic water (0.9% benzyl alcohol)
• Typical concentration: 5 mg peptide in 2 mL water = 2.5 mg/mL
• Inject water slowly down side of vial, not directly onto powder
• Gently swirl (don't shake) to dissolve
• Store in refrigerator, use within 30 days

Injection technique:

• Common sites: Abdomen (2 inches from navel), thigh, upper arm
• Clean site with alcohol swab
• Pinch skin, insert needle at 45-90 degree angle
• Inject slowly, withdraw needle
• Apply gentle pressure with alcohol swab
• Rotate injection sites to prevent tissue damage

Cycling and Tolerance Management

Why Cycling Is Important

While Semax and Selank don't produce physical dependence, cycling is recommended to:

• Prevent receptor downregulation and tolerance
• Allow natural neurotransmitter systems to recalibrate
• Maintain maximum effectiveness when used
• Reduce risk of unknown long-term effects
• Provide breaks to assess baseline cognitive function

Recommended Cycling Schedules

Standard cycle:

• On-cycle: 8-12 weeks
• Off-cycle: 4-6 weeks (half the on-cycle duration)
• Pattern: 8 weeks on, 4 weeks off, repeat

Intensive cycle:

• On-cycle: 4-6 weeks
• Off-cycle: 4-6 weeks (equal duration)
• Pattern: 4 weeks on, 4 weeks off, repeat

Maintenance cycle:

• On-cycle: 12-16 weeks
• Off-cycle: 6-8 weeks
• Pattern: 12 weeks on, 6 weeks off, repeat

Managing Off-Cycles

During breaks, support cognitive function with:

• Lifestyle factors: Quality sleep, exercise, stress management
• Nutrition: Omega-3s, B-vitamins, antioxidants
• Supplements: Lion's Mane, Bacopa, L-theanine, caffeine
• Cognitive training: Continue mental exercises and learning

Combination Strategies

Synergistic Supplements

These can enhance the Semax + Selank stack:

Choline sources (for acetylcholine support):

• Alpha-GPC: 300-600 mg daily (improves memory formation)
• CDP-Choline: 250-500 mg daily (supports focus and attention)
• Rationale: Semax increases acetylcholine activity; providing precursors enhances effects

Adaptogens (for stress resilience):

• Rhodiola rosea: 200-400 mg daily (reduces fatigue, improves stress tolerance)
• Ashwagandha: 300-600 mg daily (reduces cortisol, improves anxiety)
• Rationale: Complements Selank's anxiolytic effects

Omega-3 fatty acids:

• Dose: 2-4 grams EPA+DHA daily
• Rationale: Supports neuroplasticity, reduces inflammation, enhances BDNF effects

Caffeine + L-theanine:

• Dose: 100-200 mg caffeine + 200-400 mg L-theanine
• Timing: Morning, separate from Semax by 30-60 minutes
• Rationale: Provides additional focus and alertness without jitteriness

What NOT to Combine

Avoid these combinations:

• Other nootropic peptides: Dihexa, P21, Cerebrolysin (too many mechanisms at once)
• Strong stimulants: High-dose caffeine, amphetamines (risk of overstimulation)
• Benzodiazepines: May counteract Selank's effects
• Alcohol: Reduces cognitive benefits, may increase side effects
• MAO inhibitors: Potential interaction with neurotransmitter effects

Monitoring and Safety

What to Track

Keep a log to assess effectiveness and identify issues:

• Cognitive metrics: Focus duration, memory recall, mental clarity (1-10 scale)
• Mood and anxiety: Daily ratings, note triggers and patterns
• Sleep quality: Duration, quality, morning alertness
• Side effects: Headaches, overstimulation, nasal irritation
• Productivity: Work output, learning progress, task completion

Warning Signs to Stop

Discontinue use and consult healthcare provider if you experience:

• Severe or persistent headaches
• Significant anxiety or agitation
• Sleep disturbances (insomnia, nightmares)
• Mood changes (depression, irritability)
• Cardiovascular symptoms (chest pain, palpitations)
• Allergic reactions (rash, difficulty breathing)
• Cognitive impairment (worse than baseline)

Contraindications

Do not use this protocol if you have:

• Epilepsy or seizure disorders
• Severe anxiety or panic disorder (start with Selank only)
• Bipolar disorder or psychotic disorders
• Pregnancy or breastfeeding
• Recent stroke or TBI (without medical supervision)
• Severe cardiovascular disease
• Autoimmune conditions (Selank may modulate immune function)

Cost Analysis

Beginner Stack (4-8 weeks)

• Semax 0.1% nasal spray (10 mL): $40-60 (lasts 2-4 weeks at 300-600 mcg/day)
• Selank 0.15% nasal spray (10 mL): $40-60 (lasts 3-4 weeks at 250-500 mcg/day)
• Total monthly cost: $80-120
• 8-week cycle cost: $160-240

Standard Stack (8-12 weeks)

• Semax 1% nasal spray or injectable: $60-100/month
• Selank nasal spray or injectable: $60-100/month
• Total monthly cost: $120-200
• 12-week cycle cost: $360-600

Advanced Stack with NAD+

• Semax + Selank: $120-200/month
• NAD+ (50-100 mg, 2-3x/week): $100-200/month
• Total monthly cost: $220-400
• 12-week cycle cost: $660-1,200

Frequently Asked Questions

How quickly will I notice effects?

Most users notice subtle improvements within 1-3 days (reduced anxiety, slight focus improvement). Significant cognitive enhancement typically becomes apparent in week 1-2, with peak benefits at week 4-8.

Can I use this protocol long-term?

Cycling is recommended (8-12 weeks on, 4-6 weeks off) to maintain effectiveness and reduce unknown long-term risks. Some users in Russia use these peptides for years with cycling, but long-term safety data is limited.

Will I experience withdrawal when stopping?

No physical withdrawal occurs. Some users report feeling "less sharp" for a few days after stopping, but this is return to baseline, not withdrawal. Many cognitive benefits persist for weeks after discontinuation.

Can I use just Semax or just Selank?

Yes. Semax alone provides cognitive enhancement but may cause overstimulation in some users. Selank alone provides anxiety reduction and subtle cognitive benefits. The combination is synergistic but not required.

Is this safe for students/young adults?

Safety in individuals under 25 (when brain development completes) is not well-studied. Conservative approach: wait until 25+, or use only under medical supervision if younger.

How does this compare to prescription ADHD medications?

Different mechanisms. ADHD meds (stimulants) work immediately through dopamine/norepinephrine but can cause tolerance and dependence. Semax/Selank work through neuroplasticity, take longer to reach peak effects, but don't cause dependence and may provide lasting benefits.